Funding for this research was provided by:
Central Manchester University Hospitals NHS Foundation Trust (R02145)
Received: 10 October 2017
Accepted: 12 January 2018
First Online: 22 February 2018
Ethics approval and consent to participate
: The study was approved by the National Research Ethics Service Committee North West-Great Manchester Central (reference 13/NW/0111).
: All data generated or analysed during the study are included in this published article (and its Additional files).
: D. Gareth Evans had a travel for a trial meeting paid for by the Amgen and declared no other conflicts of interest. All other authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.