Funding for this research was provided by:
Berlin Institute of Health (Digital Health Accelerator)
Charité - Universitätsmedizin Berlin
Received: 15 February 2022
Accepted: 8 April 2022
First Online: 28 April 2022
: The study was approved by the local institutional review board (Comité d’éthique de la recherche en imagerie médicale—CERIM, reference number: CRM-2107-183), and written informed consent of patients was waived.
: Not applicable.
: F. Michallek holds a US patent (USPTO: 10991109, Patent 2021) on fractal analysis of perfusion imaging and has filed a patent application on the same topic at the European Patent Office (PCT/EP2016/071551), each together with Marc Dewey. F.M. receives grant support from the German Research Foundation (DFG, grant number Ml 2272/1-1 ), which covers 50% of his position. R. Sartoris: Nothing to disclose. A. Beaufrère: Nothing to disclose. M. Dioguardi Burgio: Nothing to disclose. F. Cauchy: Nothing to disclose. R. Cannella: R.C. is a member of the Insights into Imaging Editorial Board. He has not taken part in the review or selection process of this article. V. Paradis: Nothing to disclose. M. Ronot: Nothing to disclose. M. Dewey holds a US patent (USPTO: 10,991,109, Patent 2021) on fractal analysis of perfusion imaging and has filed a patent application on the same topic at the European Patent Office (PCT/EP2016/071551), each together with Florian Michallek. M.D. receives grant support from the German Research Foundation for this project (DFG, grant number 392304398). Prof. Dewey has received grant support from the FP7 Program of the European Commission for the randomized multicenter DISCHARGE trial (603266-2, HEALTH-2012.2.4.-2). He also received grant support from German Research Foundation (DFG) in the Heisenberg Program (DE 1361/14-1), graduate program on quantitative biomedical imaging (BIOQIC, GRK 2260/1), the Priority Programme Radiomics for the investigation of coronary plaque and coronary flow (DE 1361/19-1  and 20-1  in SPP 2177/1). He also received funding from the Berlin University Alliance (GC_SC_PC 27) and from the Digital Health Accelerator of the Berlin Institute of Health. Prof. Dewey is European Society of Radiology (ESR) Research Chair (2019–2022), and the opinions expressed in this article are the author’s own and do not represent the view of ESR. Per the guiding principles of ESR, the work as Research Chair is on a voluntary basis and only remuneration of travel expenses occurs. Prof. Dewey is also the editor of Cardiac CT, published by Springer Nature, and offers hands-on courses on CT imaging (ExternalRef removed). Institutional master research agreements exist with Siemens, General Electric, Philips, and Canon. The terms of these arrangements are managed by the legal department of Charité—Universitätsmedizin Berlin. V. Vilgrain: Nothing to disclose.