Funding for this research was provided by:
National Natural Science Foundation of China (81602893)
Natural Science Foundation of Shandong Province (ZR2015YL049)
Medical and Health Technology Development Plan Project of Shandong Province (2016WS0540)
Key Research and Development Plan of Shandong Province (2017GSF18186)
Innovation Project of Shandong Academy of Medical Science
Received: 5 January 2018
Revised: 14 March 2018
Accepted: 16 March 2018
First Online: 19 April 2018
: The animal procedures in this study were carried out in accordance with National Institutes of Health (NIH) Guidelines for the Care and Use of Laboratory Animals, with approval from the animal ethics committee of Shandong Academy of Medical Sciences.
: All authors of this manuscript agreed to publication.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.