Funding for this research was provided by:
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R61 AR073409)
Received: 12 February 2019
Revised: 8 May 2019
Accepted: 10 May 2019
First Online: 13 June 2019
: All animal procedures were performed in accordance with Good Laboratory Practice (GLP), Technical Guidelines for Research on Allergic and Hemolytic Drug Stimulants, and Technical Guidelines for Toxicity Study of Single Drug Delivery. Rats, rabbits, and non-human primates were performed in accordance with the Institutional Ethical Guidelines for Animal Experiments developed by Zhejiang Academy of Medical Sciences (Y-AP-14012). Experiments in mice and beagles were conducted in accordance with the Institutional Ethical Guidelines for Animal Experiments developed by the Sun Yat-sen University (180106). Gingival tissues were obtained from patients who underwent tooth extraction procedures, and clinical aspects of this study were approved by the ethics committee of the Third Hospital at the Sun Yat-sen University (2018-02-195-01) and consent forms were signed by donors.
: Not applicable.
: The authors declare that they have no competing interests.
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