Funding for this research was provided by:
Instituto de Salud Carlos III (PS15/01318, CP15/00069, FI17/00188, FI18/00026, RD16/0019/0005)
Agencia Estatal de Investigación (IJCI-2017-33505)
European Regional Development Fund (PS15/01318)
Received: 28 November 2019
Revised: 20 December 2019
Accepted: 11 February 2020
First Online: 19 February 2020
Ethics approval and consent to participate
: The procedure was carried out at our Cerebrovascular and Neuroscience Research Laboratory, La Paz University Hospital, Madrid, Spain. All experiments were designed to minimize animal suffering of animals in compliance and approved by our medical school’s Ethical Committee for the Care and Use of Animals in Research (Ref. PROEX 361/15), according to the Spanish (RD 1201/2005 and RD53/2013) and European Union (EU) (86/609/CEE, 2003/65/CE, 2010/63/EU) rules.
: Not applicable
: The authors declare that they have no competing interests.