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Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

Crossref DOI link: https://doi.org/10.1186/s13287-021-02362-1

Published Online: 2021-05-13

Published Print: 2021-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Sun, Yongjin

Zhang, Wenzhi

Li, Xu
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (81201383)
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Article History

Received: 9 December 2020

Accepted: 28 April 2021

First Online: 13 May 2021

Declarations

:

: This study was performed in compliance with the principles of the Helsinki Declaration and the Guidelines for the Care and Use of Laboratory Animals of the Chinese Institute of Health. Sprague–Dawley rats were purchased from the central animal laboratory of The First Affiliated Hospital of the University of Science and Technology of China. All procedures were approved by the Animal Research Committee of the First Affiliated Hospital of the University of Science and Technology of China. The Ethics Committee of the First Affiliated Hospital of the University of Science and Technology of China approved the study, and informed consent was obtained from all the donors.

: Not applicable.

: The authors declare that they have no competing interests.

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