Received: 6 April 2021
Accepted: 12 May 2021
First Online: 10 June 2021
: Procedures involving animals and their care conformed with institutional guidelines in compliance with national (D.lgs 26/2014; Authorization n.19/2008-A issued March 6, 2008 by Ministry of Health); the NIH Guide for the Care and Use of Laboratory Animals (2011 edition) and EU directives and guidelines (EEC Council Directive 2010/63/UE).All animal experimental protocols were approved by our Institutional Committee (IACUC, IRFMN Animal Care and Use Committee) at the Istituto di Ricerche Farmacologiche Mario Negri IRCCS, which includes “ad hoc” members for ethical issues. Animals were housed in the Institute’s Animal Care facilities, which meet international standards.
: Not applicable
: The authors declare that they have no competing interests.