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Article History

Received: 16 January 2023

Accepted: 19 July 2023

First Online: 28 July 2023

Declarations

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: The experimental procedures involving live animals were performed in strict accordance with the European directive (2010/63/EU), the Italian Law for Care and Use of Experimental Animals (DL116/92) and the University of Turin institutional guidelines on animal welfare and authorized by the Italian Ministry of Health (Authorizations: 977–2016-PR and 327/2020-PR). Additionally, the ad hoc Ethical Committee of the University of Turin specifically approved this study. Title of ethical-approved project: “Strategie di sostituzione cellulare e di riprogrammazione in situ in modelli di roditore di morbo di Huntington” [Cell replacement and in situ reprogramming strategies in rodent models of Huntington's disease]; date of approval: April 8, 2020. Surgical procedures were performed under general anesthesia (4% isoflurane) and animals were observed daily after surgery. Animals were carefully handled before and during the experiments to lessen their affliction. All animal experiments were performed during the light period and at the same time in the Neuroscience Institute Cavalieri Ottolenghi of University of Turin.

: Not applicable.

: The authors declare that they have no competing interests.