Funding for this research was provided by:
Horizon 2020 (635408)
Agencia Canaria de Investigación, Innovación y Sociedad de la Información (TESIS2017010080)
European Social Fund (TESIS2017010080)
Universidad de Las Palmas de Gran Canaria (PIFCABILDO-2017-CCSALUD-2)
“la Caixa” Foundation
Fundación Canaria Universitaria de Las Palmas
Cabildo Insular de Gran Canaria (PIFCABILDO-2017-CCSALUD-2)
Received: 1 February 2021
Accepted: 20 May 2021
First Online: 16 June 2021
: Experiments were approved by the Animal Welfare Ethics Committee of the Universidad de Las Palmas de Gran Canaria (OEBA_ULPGC_003_2014) and from the local authorities, following the rules of the Spanish Legislation (RD 53/2013). Several animals presented local granulomas in the injection area. They were followed by the researchers and all of them resolved and they had no systemic consequences. One lamb in the CHB-vaccine group died a few days after the start of the procedure from a post-traumatic renal haemorrhage. It was not related to animal handling. We followed the ARRIVE guidelines published in the online journal PLoS Biology in June 2010.
: The authors declare that they have no competing interests.