Gerovska, Daniela http://orcid.org/0000-0003-0671-4277
Noer, Julie B.
Qin, Yating
Ain, Quratul
Januzi, Donjetë
Schwab, Matthias
Witte, Otto W.
Araúzo-Bravo, Marcos J. http://orcid.org/0000-0002-3264-464X
Kretz, Alexandra http://orcid.org/0000-0001-5880-603X
Funding for this research was provided by:
Else Kröner-Fresenius-Stiftung (EKFS)
Deutsche Forschungsgemeinschaft (WI 830/12-1)
TMWWDG (RegenerAging-52-5581-413-FSU-I-03/14)
Center for Clinical and Translational Research (FF01)
HORIZON EUROPE European Innovation Council (899417)
Ministerio de Ciencia e Innovación (PID2020-119715GB-I00/AEI/10.13039/501100011033)
Instituto de Salud Carlos III (iDATA-MP, iDATA-MP)
Innovationsfonden (8088-00049B)
Carlsbergfondet (CF21-0167)
Novo Nordisk Fonden (NNF21OC0072023)
Universitätsklinikum Jena
Article History
Received: 3 July 2023
Accepted: 27 August 2023
First Online: 13 September 2023
Declarations
:
: All animal experiments were carried out in accordance with the ‘Animal Research: Reporting of In Vivo Experiments (ARRIVE)’ guidelines and approved by the animal welfare authorities of the State of Thuringia (accreditation number: UKJ-18-004). All animal-based procedures adhered to current European Union regulations and the Directives of the Protection of Animals Act. Animals were housed at the center of experimental animal care (ZET) at the Jena University Hospital (Jena, Germany) according to current standards of animal welfare, including controlled conditions of humidity, temperature, 14 h/10 h light/dark cycles and with <i>ad libitum</i> access to standard diet and water. Mice used were raised on an identical C57BL/6 J background and are expected to be isogenic in the control (<i>n</i> = 10) and co-isogenic with the <i>hSOD1</i><sup><i>G93A</i></sup> mutant animals (<i>n</i> = 9). Though assumed to be homozygous at all <i>loci,</i> some minor variants might exist, for which a specific screen, however, was not performed.
: All authors have given their consent for publication.
: The authors declare no competing interests.