Received: 6 December 2019
Accepted: 11 June 2020
First Online: 26 June 2020
Ethics approval and consent to participate
: PROXIMA was conducted according to the ethical principles of the Declaration of Helsinki and the Italian Medicines Agency (AIFA) Guideline for the classification and management of observational studies on drugs [36–38]. All patients provided informed consent before participating in the study.
: Enrico Heffler is an advisory board member and speaker for Novartis, AstraZeneca, Sanofi-Genzyme, GSK, Teva, Circassia, and Nestlè Purina. Fabiana Saccheri and Marta Bartezaghi are employees of Novartis. Giorgio Walter Canonica has received research grants, as well as lecture or advisory board fees, from A. Menarini, Alk-Abello, Allergy Therapeutics, Anallergo, AstraZeneca, MedImmune, Boehringer Ingelheim, Chiesi Farmaceutici, Circassia, Danone, Faes, Genentech, Guidotti-Malesci, GlaxoSmithKline, Hal Allergy, Merck, MSD, Mundipharma, Novartis, Orion, Sanofi-Aventis, Sanofi, Genzyme/Regeneron, Stallergenes, UCB Pharma, Uriach Pharma, Teva, Thermo Fisher, and Valeas.