Received: 28 October 2020
Accepted: 26 April 2021
First Online: 6 May 2021
: Not applicable.
: All authors approved this version of the manuscript.
: We have no known conflicts of interest to disclose apart from the following. Jørn Wetterslev and Christian Gluud are members of the taskforce at Copenhagen Trial Unit (CTU) to develop theory and software for doing trial sequential analysis (TSA) currently freeware available including a manual at ExternalRef removed.