Plumb, James O. M.
Otto, James M.
Kumar, Shriya B.
Bali, Sitara
Wakatsuki, Mai
Schmidt, Walter F. J.
Montgomery, Hugh E.
Grocott, Michael P. W.
Levett, Denny Z.
Funding for this research was provided by:
Pharmacosmos A/S, Holbaek, Denmark,
National Institute for Health Research Southampton Biomedical Research Centre
University College London Hospitals Biomedical Research Centre
Article History
Received: 23 May 2022
Accepted: 16 June 2023
First Online: 3 July 2023
Declarations
:
: Ethical approval was granted by the London—Surrey Research Ethics Committee and NHS Health Research Authority (REC reference 17/LO/2061). Local permissions were received from the University of Southampton (ERGO ID: 31688), University Hospital Southampton NHS Foundation Trust (R&D CRI 0357) and Southampton Centre for Biomedical Research Clinical Research Facility. The study was performed in accordance with the ethical standard set by the Declaration of Helsinki. Written informed consent was obtained from all participants.
: As above all patients were formally consented.
: JOMP: Received financial support from Siemens Healthcare Ltd for consumables and hardware for research into the measurement of haemoglobin mass (2015–2018). JOMP was given consumables from Intersurgical UK Ltd (2015–2018); has received honoraria for speaking and/or travel expenses from Siemens, Vifor Pharma and Pharmacosmos Ltd. JOMP has received unrestricted grant funding from Pharmacosmos Ltd. JOMP is unaware of any direct or indirect conflict of interest with the contents of this paper or its related fields. The design of this study was researcher led with no input from Pharmacosmos Ltd.JMO: No conflicts of interest.SK: No conflicts of interest.SB: No conflicts of interest.MW: Received honoraria for speaking and/or travel expenses from Pharmacosmos Ltd.WS: Managing partner of the company ‘Blood tec GmbH’, but he is unaware of any direct or indirect conflict of interest with the contents of this paper.HEM: On the Council of the UK Intensive Care Society but is unaware of any direct or indirect conflict of interest with the contents of this paper or its related fields.MPWG: Vice-president of CPX International. He also serves on the medical advisor board of Edwards Lifesciences and the board of EBPOM Community Interest Company, Medinspire Ltd and Oxygen Control Systems Ltd. He has received honoraria for speaking for and/or travel expenses from BOC Medical (Linde Group), Edwards Lifesciences and Cortex GmBH and unrestricted research support from Sphere Medical Ltd and Pharmacosmos Ltd. He leads the Fit-4-Surgery research collaboration and the Xtreme Everest oxygen research consortium, which has received unrestricted research grant funding from BOC Medical (Linde Group), Deltex Medical and Smiths Medical. He was funded in part from the British Oxygen Company Chair of the Royal College of Anaesthetists awarded by the National Institute of Academic Anaesthesia. All funding was unrestricted. The funders had no role in study design, data collection and analysis, decision to publish or the preparation of the manuscript. This work was conducted at the Southampton NIHR Biomedical Research Centre with subjects studied within the Southampton NIHR Clinical Research Facility.DZL: On the board of CPX International a society supporting cardiopulmonary exercise testing and a member of the fit-4-surgery research group in Southampton. DL has received unrestricted research support from Pharmacosmos Ltd. The funders had no role in study design, data collection and analysis, decision to publish or the preparation of the manuscript. This work was conducted at the Southampton NIHR Biomedical Research Centre with subjects studied within the Southampton NIHR Clinical Research Facility.