Received: 22 March 2020
Accepted: 29 October 2020
First Online: 23 November 2020
Ethics approval and consent to participate
: Plasma drug concentration analyses in pregnant women in our series had been requested by their treating gynaecologists/obstetricians. The corresponding results were extracted from the existing clinical records of PT patients and transferred to a coded data base for evaluation. Because of the retrospective observational nature of the study and the lack of any modification in the management of patients, the need for informed consent was waived. The remnants of serum samples of patients with OT had been stored after routine analyses for drug tolerability after approval of the biobank by the institutional ethics committee, Kantonale Ethik-Kommission Bern, registration number 152/08. All but one patient were above 18 years of age at the time of sampling and had signed informed general consent approving the use of their coded data and biomaterials collected during their therapy at our institution.
: JGG acts as advisor for several pharmaceutical companies and contributes to several clinical studies. The underlying manuscript is independent of these activities. None of the authors received direct or indirect support for this study or have any conflicting interests with the data that are presented herein. None of the other authors report any potential conflict of interest.