Funding for this research was provided by:
National Institutes of Health (2RO1-HD045962, R01-HD075285)
Canadian Institutes of Health Research (THC-135233)
Natural Sciences and Engineering Research Council of Canada (RGPIN-2014-06664)
Canada First Research Excellence Fund (Medicine by Design)
Compute Canada (SciNet HPC Consortium)
Received: 22 March 2017
Accepted: 20 August 2017
First Online: 6 September 2017
: All animal protocols adhered to the University of Colorado Denver Institutional Animal Care and Use Committee (IACUC) guidelines.
: Not applicable.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.