Funding for this research was provided by:
Ministerio de Economía, Industria y Competitividad, Gobierno de España (AGL2013-44761-P, IJCI-2015-23196, BES-2014-068736)
Received: 23 July 2018
Accepted: 11 June 2019
First Online: 4 July 2019
Ethics approval and consent to participate
: Ethical approval for this study was obtained from the Bioethics Committee of CSIC (Consejo Superior de Investigaciones Científicas) and from the Regional Ethics Committee for Clinical Research (Servicio de Salud del Principado de Asturias n°112/13).
: Not applicable.
: The authors declared that they have no competing interests.