Funding for this research was provided by:
Horizon 2020 Framework Programme (Health-F2-2009-241913)
Instituto de Salud Carlos III (PI16/02173, CP18/00009)
Received: 13 October 2020
Accepted: 18 March 2021
First Online: 7 May 2021
: Human study: All subjects gave written informed consent, validated and approved by the ethical committee of the Hospital Universitari Dr Josep Trueta (Comitè d’Ètica d’Investigació Clínica, approval number 2009 046) and Policlinico Tor Vergata University of Rome (Comitato Etico Indipendente, approval number 28-05-2009).Animal procedures for mice studies 1 and 2 were approved by the Institutional Animal Care and Use Committee of the University of Utah. For study 3, all animal experimental procedures were approved by the local ethical committee (approval number 31-278) of Rangueil University Hospital (Toulouse, France) and conducted in strict accordance with the guidelines of the European Communities Directive 86/609/EEC regulating animal research.
: Not applicable.
: The authors declare that they have no competing interests.