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Combined RT-qPCR and pyrosequencing of a Spike glycoprotein polybasic cleavage motif can uncover pediatric SARS-CoV-2 infections associated with heterogeneous presentation

Crossref DOI link: https://doi.org/10.1186/S40348-021-00115-X

Published: 2021-12

Update policy: https://doi.org/10.1007/SPRINGER_CROSSMARK_POLICY

Authors

Weil, Patrick Philipp

Hentschel, Jacqueline

Schult, Frank

Pembaur, Anton

Ghebremedhin, Beniam

Mboma, Olivier

Heusch, Andreas

Reuter, Anna-Christin

Müller, Daniel

Wirth, Stefan

Aydin, Malik

Jenke, Andreas C. W.

Postberg, Jan http://orcid.org/0000-0002-8562-3316
Funding

Funding for this research was provided by:

Private Universität Witten/Herdecke gGmbH
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Text and Data Mining valid from 2021-04-24

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Article History

Received: 15 December 2020

Accepted: 7 April 2021

First Online: 24 April 2021

Declarations

:

: For the collection and use of specimens at Helios University Hospital Wuppertal (North Rhine-Westphalia, West Germany) and Klinikum Kassel (Hessen, Central Germany) we obtained approval from the Witten/Herdecke University Ethics board (covered by “CoronaKids” [No. 61/2020] and No. 160/2020 for the use of routinely sampled and confirmed specimens for RT-qPCR/pyrosequencing method establishment). All work has been conducted according to the principles expressed in the Declaration of Helsinki.

: Informed written consent was obtained from the legal guardians of the involved children.

: The authors declare that they have no competing interests.

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