Received: 10 January 2021
Accepted: 26 April 2021
First Online: 7 May 2021
: The Hokkaido University Animal Research Committee approved all experimental procedures and methods of animal care (study approval no.: 13–0074). The Animal Care Guidelines for the Care and Use of Laboratory Animals of Hokkaido University Graduate School of Medicine and the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health were applied to all experiments.
: Not applicable.
: The authors declare that they have no conflicts of interest associated with this manuscript.