Funding for this research was provided by:
National Natural Science Foundation of China (81973116 and 81573229, 91846302, 81502870)
National Key Research and Development program of China (2017YFC0907002, 2017YFC0907003)
International S&T Cooperation Program of China (2015DFE32790)
European Research Council (682663)
Shandong Provincial Natural Science Foundation (ZR2020QH302)
Received: 25 November 2020
Accepted: 4 February 2021
First Online: 17 February 2021
Ethics approval and consent to participate
: The study protocol was approved by the Institutional Review Boards of the School of Life Sciences, Fudan University (date: February 19, 2009), Qilu Hospital, Shandong University (date: March 8, 2010), and Stockholm Ethical Vetting Board (2018/357–31). The study was carried out in accordance with the approved protocol, and all participants provided written informed consent.
: We have received consents from all participants involving in this study. The consent forms will be provided upon request.
: The authors declare no potential conflicts of interest.