Funding for this research was provided by:
FP7 Ideas: European Research Council (ERC AdG 339842)
Deutsche Forschungsgemeinschaft (EXC2180- 390900677, We-4195/14-1)
Ernst Jung Preis (-/-)
Faculty of Medicine Carl Gustav Carus of the Technische Universität Dresden (-/-)
Federal State Baden-Württemberg (-/-)
Text and Data Mining valid from 2019-11-15
Received: 10 June 2019
Accepted: 30 October 2019
First Online: 15 November 2019
Ethics approval and consent to participate
: Human samples used for this study were unanimously obtained after informed consent in accordance with the rules set forth by the Declaration of Helsinki of the World Medical Association. For the vaccinated individual special conditions apply (see also Ethical considerations in the Materials and Methods section), since the interventions were performed as self-experimentation by an investigator and designer of the research himself on his own person. As the Declaration of Helsinki does not comment on self-experimentation the requirement for ethics approval does not apply, whereas it is widely accepted that in absence of coercion or dependency this form of interventions is an ethically and legally legitimate form of experimentation. For reference samples received from healthy blood donors Institutional Review Board approval was obtained.
: Written informed consent for publication was obtained and a consent form signed by the vaccinated individual was made available to the Editor.
: H.G. Rammensee has ownership interest (including patents) in Immatics Biotechnologies GmbH, CureVac AG, and Synimmune GmbH, further he shares the patent for XS15.M.W. Löffler, D.J. Kowalewski, H. Schuster, S. Stevanović, and S.P. Haen are the inventors of patents for vaccine peptides owned by Immatics. D.J. Kowalewski, L. Backert, and H. Schuster are currently employees of Immatics Biotechnologies. P. Anoop Chandran is an employee of Adaptimmune Therapeutics Ltd. H. Zelba is employed by CeGaT GmbH.K.H. Wiesmüller shares the patent for XS15 and holds ownership interest in EMC microcollections GmbH.No competing interests were disclosed by the other authors.