Funding for this research was provided by:
Pfizer Foundation (NA)
Text and Data Mining valid from 2019-12-01
Received: 6 September 2019
Accepted: 11 November 2019
First Online: 4 December 2019
Ethics approval and consent to participate
: The study was conducted in compliance with the ethical principles originating in or derived from the Declaration of Helsinki and in compliance with the International Council for Harmonisation Good Clinical Practice Guidelines. All patients provided written informed consent. The final protocol, any amendments and informed consent documentations were reviewed and approved by the Institutional Review Boards at each of the investigational centers participating in the study.
: Not applicable.
: EC has received funding from AstraZeneca, Amgen, Bayer, Bristol-Myers Squibb, MSD, and Merck; MP has no conflicts of interest. DS has no conflicts of interest that directly affect this trial, has received research funding from Pfizer, BMS, Celgene, Leap, and Alkermes; is consultant for Sanofi/Genzyme, Aduro, Eli Lilly, AstraZeneca, and Ipsen; and is on the speakers’ bureau for Eli Lilly, Genentech, and Celgene; MLJ has received research funding from BerGenBio, Eli Lilly, EMD Serono, Janssen, Mirati Therapeutics, Genmab, Pfizer, AstraZeneca, Genentech/Roche, Stemcentrix, Novartis, Checkpoint Therapeutics, Array Biopharma, Regeneron, Apexigen, AbbVie, Tarveda, Adaptimmune, Syndax, Neovia, Boehringer Ingelheim, Sanofi, Hengrui Therapeutics, INC, Merck, Daiichi-Sankyo, Lycera, G1 Therapeutics, Dynavax, LOXO, Cytomx, BeiGene, Birdie, Corvus, Incyte, Genocea, Gritstone, Amgen, Bristol-Myers Squibb, Kadmon, Clovis, Acerta, OncoMed, and Guardant Health; and has served as a consultant for Genentech/Roche, Celgene, Boehringer Ingelheim, Sanofi, Mirati Therapeutics, LOXO, Calithera, AstraZeneca, Merck, Araxes Pharma, Mersana Therapeutics, BeiGene, Incyte, Pfizer, Guardant Health, Bristol-Myers Squibb, and Ribon Therapeutics. CC has received honoraria for advisory boards with Bristol-Myers Squibb, AstraZeneca, Celgene, Ignyta, CUE Biopharma, and Eli Lilly. SP has received research funding from Merck, Pfizer, Bristol-Myers Squibb, Vyriad, Genentech, and Novartis and has served as a consultant for Bristol-Myers Squibb. DW has no conflicts of interest. JW has received research funding from AstraZeneca, Merck, Pfizer, Celgene, Novartis, and G1 and is consultant and served on advisory panels for AstraZeneca, Pfizer, Nanobiotox, G1, and Immunicum. YC, CBD, BH, FT, and AT are employees of Pfizer and hold stock in Pfizer.