Funding for this research was provided by:
National Institutes of Health (R35 NS097273, R35 NS097261, P01 NS084974, U01 AG045390, P50 AG016574, R21 NS099631, U54 NS092089, R21 NS110994)
Amyotrophic Lateral Sclerosis Association (18-IIA-417)
Robert Packard Center for ALS Research, Johns Hopkins University (N/A)
Received: 7 August 2019
Accepted: 24 August 2019
First Online: 8 October 2019
Ethics approval and consent to participate
: The Brain Bank for Neurodegenerative Disorders at Mayo Clinic operates under IRB ID:15 009452 (Full Title: “Mayo Clinic Florida Brain Bank”). Research on autopsy samples is considered exempt from Human Subjects Research under Federal Regulation 45 CFR 46.101. All autopsies are obtained after consent by the legal next-of-kin or someone legally authorized to make this decision. Autopsies are performed with the explicit assumption that tissue will be used for both diagnostic evaluation and research.
: Not applicable.
: MDJ and RR hold a patent on methods to screen for the hexanucleotide repeat expansion in the <i>C9orf72</i> gene. All other authors declare that they have no competing interests.