Funding for this research was provided by:
H2020 European Research Council (681181)
Alzheimer's Society (AS-PG-15b-023)
UK Dementia Research Institute
Received: 11 November 2019
Accepted: 13 November 2019
First Online: 20 December 2019
Ethics approval and consent to participate
: Use of human tissue for post-mortem studies has been reviewed and approved by the Edinburgh Brain Bank ethics committee and the ACCORD medical research ethics committee, AMREC (ACCORD is the Academic and Clinical Central Office for Research and Development, a joint office of the University of Edinburgh and NHS Lothian — Ethics approval reference 15-HV-016). The Edinburgh Brain Bank is a Medical Research Council funded facility with research ethics committee (REC) approval (16/ES/0084). Tissue from 33 donors was used for this study and their details are found in Table InternalRef removed.
: TSJ is a member of the scientific Advisory Board of Cognition Therapeutics. The company had no influence over the experiments reported in this paper.