Funding for this research was provided by:
Japan Society for the Promotion of Science (Grant-in-Aid for Challenging Exploratory Research (2567025), Grant-in-Aid for Scientific Research (B) (18H02606), Grant-in-Aid for Challenging Research (Exploratory) (17K19637))
Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research on Innovative Areas “Platform of Advanced Animal Model Support” (16H06276))
Keio University (Program for the Advancement of Research in Core Projects under Keio University’s Longevity Initiative)
Suntory Global Innovation Center Ltd. (program “Water Channeling Life”)
Received: 23 January 2020
Accepted: 21 April 2020
First Online: 12 May 2020
Ethics approval and consent to participate
: This article does not contain any studies with human participants performed by any of the authors.All animal experiments were performed according to the Act on Welfare and Management of Animals and related Japanese governmental guidelines and regulations. Those in Keio University, in Sophia University, and Fujita Health University were approved by Institutional Animal Care and Use Committee at Keio University (09084–11 and 16076–2), at Sophia University (2016–19), and at Fujita Health University (AP16016), respectively.
: Not applicable.
: Masato Yasui has received funding for the research from Suntory Global Innovation Center Ltd.The other authors declare that they have no competing interests.