Funding for this research was provided by:
Japan Agency for Medical Research and Development (19dm0107110, JP18ek0109391, JP18dm0207019)
Core Research for Evolutional Science and Technology (JPMJCR18H3)
Received: 11 August 2020
Accepted: 10 October 2020
First Online: 28 October 2020
Ethics approval and consent to participate
: The analysis involving human material was approved by the ethics committees of the Tokyo Metropolitan Matsuzawa Hospital (No. 2019-28), Aichi Medical University (No. 2019-M019), and University of Tsukuba (No. 1271) and was performed in accordance with the ethical standards laid down in the 1964 declaration of Helsinki and its later amendments. The animal experiments were approved by the ethics committee in the Tokyo Metropolitan Institute of Medical Science (No. 19082). We designed the animal experiment very carefully to minimize the number of animals used according to animal protection considerations based on the 3R (reduce, reuse, recycle) principle.
: Informed consent was obtained from the patients’ next of kin.
: The authors declare that they have no competing interests.