Funding for this research was provided by:
The Ministry of Education, Culture, Sports, Science and Technology (20K17969)
The Ministry of Education, Culture, Sports, Science and Technology (17K10865, 20K07618, 20K17931, 18K16560)
The Ministry of Education, Culture, Sports, Sciences, and Technology (17H04303)
The Japan Agency for Medical Research and Development (18072932, 20318557)
The Ryobi Teien Memory Foundation for biological research
Received: 27 November 2020
Accepted: 30 January 2021
First Online: 22 February 2021
: All authors declare no potential conflicts of interest.
: This study was approved by the ethical committee of the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan (Approval No. 1608-026). All patients included in the study had provided informed written consent. All animal procedures and protocols were approved by the Committee on the Ethics of Animal Experimentation at Okayama University (Approval No. OKU-2018456). All procedures performed in experiments involving human participants were conducted in accordance with the ethical standards of the institution and the 1964 Helsinki declaration and its later amendments or comparable ethical standards.