Funding for this research was provided by:
National Institute of Neurological Disorders and Stroke (R01NS109532)
Received: 16 August 2021
Accepted: 8 September 2021
First Online: 26 September 2021
: The use of autopsy human brain tissues was authorized by the Institutional Review Board of University Hospital Cleveland Medical Center and Case Western Reserve University (CWRU), Cleveland, Ohio. The written informed consents by the patients during life or their next of kin after death were received for each case through the National Prion Disease Pathology Surveillance Center (NPDPSC), CWRU, Cleveland, Ohio, for research on brain samples. Post mortem examinations, if permission was available, were carried out in NPDPSC. All information was analyzed anonymously. Animal experiment was performed following a protocol reviewed and approved by the Institutional Animal Care and Use Committee of CWRU and Case Medical Center, Cleveland, Ohio, and University of Chicago, Illinois, USA.
: The manuscript contains no any individual person’s data in any form.
: The authors report no competing interests.