Funding for this research was provided by:
alzheimer's association (AARF-19-615258)
universidad de castilla-la mancha
national institutes of health (R01 EB017255, P01 AG017586)
national institute on aging (P30 AG010124, R01 AG054519)
foundation for the national institutes of health (R01 AG056014)
Received: 7 October 2021
Accepted: 11 October 2021
First Online: 24 October 2021
: Human brain specimens were obtained in accordance with the University of Pennsylvania Institutional Review Board guidelines, and the Ethical Committee of UCLM. Where possible, pre-consent during life and, in all cases, next-of-kin consent at death was given.
: All authors have reviewed the contents of the manuscript being submitted, approved of its contents and validated the accuracy of the data and consented to publication.
: D.A.W has received grant support from Merck, Biogen, and Eli Lilly/Avid. D.A.W received consultation fees from Neuronix and is on the DSMB for a clinical trial run by Functional Neuromodulation. L.X. received personal consultation fees from Galileo CDS, Inc. J.Q.T. may accrue revenue in the future on patents submitted by the University of Pennsylvania wherein he is co-Inventor and he received revenue from the sale of Avid to Eli Lily as co-inventor on imaging related patents submitted by the University of Pennsylvania.