Funding for this research was provided by:
Health Research Council of New Zealand (15/479, 16/597, 21/710)
Neurological Foundation of New Zealand (1846WF)
Lottery Health Research (LHR-2020-127339)
Received: 9 February 2022
Accepted: 11 March 2022
First Online: 24 March 2022
: All human brain tissue protocols in this study were approved by the University of Auckland Human Participants Ethics Committee (2008/279 and 011654), and all families provided informed consent. Venous blood was collected from healthy donors with informed consent under the ethical approval of the Southern Health and Disability Ethics Committee (Wellington, New Zealand [URA/06/12/083]). Mice were obtained from the Biomedical Research Facility, University of Otago, New Zealand. All stroke procedures were performed in accordance with the guidelines on the care and use of laboratory animals set out by the University of Otago, Animal Research Committee (AUP-19–160). Studies undertaken using these APP/PS1 mice animals were approved by the University of Otago Animal Ethics Committee (AUP-19–82). All methods were carried out in accordance with the approved guidelines and New Zealand animal welfare legislation.
: Not applicable.
: The authors declare that they have no competing interests.