Guo, Zhen
Tian, Chen
Shi, Yang
Song, Xue-Ru
Yin, Wei
Tao, Qing-Qing
Liu, Jie
Peng, Guo-Ping
Wu, Zhi-Ying
Wang, Yan-Jiang
Zhang, Zhen-Xin
Zhang, Jing http://orcid.org/0000-0002-7222-8317
Funding for this research was provided by:
Natural Science Foundation of China (82020108012, 82201560)
Innovation Translational Research Fund of Zhejiang University for Year 2020
National Health and Disease Human Brain Tissue Resource Center Construction National Ministry of Science and Technology
Leading Innovation and Entrepreneurship Team in Zhejiang Province (2020R01001)
Article History
Received: 19 December 2023
Accepted: 21 December 2023
First Online: 5 March 2024
Declarations
:
: The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments for experiments involving humans. Meanwhile, the Cryo-EM, NTA, WB, STORM and NanoFCM study protocols using human blood samples were approved by the clinical research ethics committees of the First Affiliated Hospital, College of Medicine, Zhejiang University (approval number: 2021-400). The IHC protocol using human brain samples was approved by the clinical research ethics committees of the First Affiliated Hospital, College of Medicine, Zhejiang University (approval number: 2022-043). The experiment involving mice was approved by the animal experimental ethical inspection committees of the First Affiliated Hospital, College of Medicine, Zhejiang University (approval number: 2021-667) and performed in accordance with Chinese Laboratory Animal Guideline for ethical review of animal welfare (2018/09) for the care of laboratory animals.
: All human subjects gave written informed consent before sample collection.
: Not applicable.
: The authors report no relevant financial interests or potential conflicts of interest.