Funding for this research was provided by:
Fondo Nacional de Desarrollo Científico y Tecnológico (1171463, 11180987, 1170893, 1160800, 1151008)
Comisión Nacional de Investigación Científica y Tecnológica (21140027)
Instituto Milenio (IMII P09/016-F)
Dirección de Investigación Medicina-UC (16-240)
Text and Data Mining valid from 2020-04-15
Received: 11 October 2019
Accepted: 6 April 2020
First Online: 15 April 2020
Ethics approval and consent to participate
: The present study was approved by the Scientific Ethics Committee of the Faculty of Medicine, Pontificia Universidad Católica de Chile, and was conducted in accordance with the tenets of the 1964 Helsinki declaration and its subsequent amendments. The clinical sample used to develop and establish the primary culture was obtained after the patient signed the written informed consent form. Mouse husbandry and animal experiments were conducted in accordance with the recommendations of the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. For injections of cancer cells, mice were anesthetized under 3% isoflurane for induction of anesthesia and 1.5% for maintenance. At the end of the assay, mice were euthanized using carbon dioxide (CO<sub>2</sub>) overdose. The protocol was approved by the Committee on Animal Experimentation, Pontificia Universidad Católica de Chile (Protocol No CBB-224/2014).
: Not applicable.
: The authors declare that they have no competing interests.