Funding for this research was provided by:
National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2012ZX09101103, 2013ZX09101002, 2008ZX09312)
Shanghai Zhangjiang Biotechnology Co., Ltd.
Chinese National Major Project (2012ZX09101103, 2013ZX09101002-001-001, 2008ZX09312)
Received: 24 July 2018
Accepted: 10 May 2019
First Online: 24 May 2019
Ethical approval and consent to participate
: This study was approved by the ethical review committee of each participating hospital in China. It was conducted in accordance with the principles of the Declaration of Helsinki and the International Conference on Harmonization of Good Clinical Practice. All participating patients provided written informed consent.
: Not applicable.
: The authors declare that they have no competing interests.