Funding for this research was provided by:
Received: 10 May 2018
Accepted: 16 January 2019
First Online: 4 February 2019
Ethics approval and consent to participate
: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Informed consent was obtained from all individual participants included in the study.
: Not applicable
: H. Gelhorn, R. Speck, W. R. Lenderking, and L. Murray participated in this project as employees of Evidera, a company which performs work for hire for multiple pharmaceutical and device companies in outcomes research. S. Tong, and P. Lin are employees of Plexxikon Inc.; H. Hsu is a medical consultant for Plexxikon Inc.; G. Maclaine is an employee of Daiichi Sankyo UK Ltd.; W. Tap and J. Healey have previously consulted for Daiichi Sankyo and Plexxikon. Xin Ye is an employee of Daiichi Sankyo Inc. which provided funding for this study. S. Bukata and R. Lackman have no conflicts of interest to report.
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