Received: 12 November 2019
Accepted: 6 March 2020
First Online: 4 May 2020
Ethics approval and consent to participate
: Study procedure were approved by the ethical committee of Ospedale Policlinico San Martino IRCCS Genoa, Italy and all subjects and/or their legal representative gave an informed consent to participate in the study.
: All subjects and/or their legal representative gave an informed consent to public the results of the study.
: MP receives research support from Novartis and received honoraria from Merck and Novartis.FN has received fees for board participation by Roche and Eli-Lilly, and speaker honoraria from Eli-Lilly.SM has received speaker honoraria from GE healthcare and Eli Lilly.GLM has received honoraria for lecturing, travel expenses for attending meetings and financial support for research from Bayer Schering, Biogen Idec, Sanofi Aventis, Teva, Genzyme, and Merck Serono Pharmaceuticals.The other authors declare that they have no competing interests.