Funding for this research was provided by:
Bundesministerium für Bildung und Forschung (01GM1514A)
Text and Data Mining valid from 2019-02-28
Received: 21 December 2018
Accepted: 20 January 2019
First Online: 28 February 2019
Ethics approval and consent to participate
: The protocol conforms to the principles of the declaration of Helsinki and was approved by the ethic committees of each local medical faculty at every study site. The leading ethic committee was located at the Medical Faculty of the University of Wuerzburg (reference number 251/16_ff-sc).All patients have to give their written consent on study participation. Patients need to be informed about the study in detailed fashion by their treating physician and must obtain sufficient time for consideration. Specific risks of the particular interventions are separately explained by the responsible specialists (BoNT treatment: neurologist, DBS operation: neurosurgeon, general anaesthesia: anaesthesiologist).
: Not applicable.
: TMO received honoraria from Allergan.PUH reports grants from German Ministry of Research and Education, German Research Foundation, European Union, Charité–Universitätsmedizin Berlin, Berlin Chamber of Physicians, German Parkinson Society, University Hospital Würzburg, Robert Koch Institute, German Heart Foundation, University Göttingen (within FIND-AF randomized, supported by an unrestricted research grant to the University Göttingen from Boehringer-Ingelheim), University Hospital Heidelberg (within RASUNOA-prime, supported by an unrestricted research grant to the University Hospital Heidelberg from Bayer, BMS, Boehringer-Ingelheim, Daiichi Sankyo), grants from Charité–Universitätsmedizin Berlin (within Mondafis, supported by an unrestricted research grant to the Charité from Bayer), outside the submitted work.JV reports consultancy work for Medtronic, Boston Scientific and Newronika. Research grants were provided by Boston Scientific and Medtronic. He received honoraria from Medtronic, Boston Scientific, Newronika, Zambon, Abbott St. Jude, UCB, Desitin, Allergan and IPSEN.
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