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Simultaneous Target-Mediated Drug Disposition-Pharmacodynamic (TMDD-PD) Modeling of Finasteride and Dutasteride: Impact of Target Binding and Turnover on Non-linear Pharmacokinetics

Crossref DOI link: https://doi.org/10.1208/s12248-025-01142-6

Published Online: 2025-12-09

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Iwaki, Yuki https://orcid.org/0009-0009-5022-8357
Lee, Wooin https://orcid.org/0000-0001-7805-869X
Aoki, Yasunori https://orcid.org/0000-0002-5881-2023
Sugiyama, Yuichi https://orcid.org/0000-0002-8452-8835
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Text and Data Mining valid from 2025-12-09

Version of Record valid from 2025-12-09
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Article History

Received: 17 May 2025

Accepted: 9 September 2025

First Online: 9 December 2025

Declarations

:

: The authors declare that they have no conflicts of interest related to this work. Y.I. is an employee of Janssen Pharmaceutical K.K., Tokyo, Japan. Y.A. is an employee of AstraZeneca, Gothenburg, Sweden.

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