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Article History

Received: 20 October 2025

Accepted: 23 December 2025

First Online: 10 February 2026

Declarations

:

: All (pooled and Individual) human plasma and serum lots were obtained from BioIVT, LLC (NY, USA). The authors state that they have followed the principles outlined in the Declaration of Helsinki for all human experimental investigations.

: All authors are employed at Boehringer Ingelheim Pharmaceuticals Inc. in Ridgefield, CT. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.