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Spatiotemporal Profiling of Intratumoral Free Payload Distribution via MALDI Imaging Mass Spectrometry: Implications for Drug-to-Antibody Ratio Optimization in Antibody–Drug Conjugates

Crossref DOI link: https://doi.org/10.1208/s12248-026-01235-w

Published Online: 2026-04-03

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cai, Tingting https://orcid.org/0009-0006-0847-8051
Li, Ziyi https://orcid.org/0009-0008-1336-2808
Yan, Qiaofang https://orcid.org/0009-0004-7626-8967
Huang, Guangcun https://orcid.org/0000-0003-1695-1153
Jia, Kaiying https://orcid.org/0009-0003-6132-8560
Chen, Xiaotong https://orcid.org/0009-0004-6325-5374
Dun, Junling https://orcid.org/0009-0003-4670-0598
Zou, Jinghua https://orcid.org/0009-0003-6921-332X
Tan, Meiling https://orcid.org/0000-0003-0173-1924
Wu, Yue https://orcid.org/0000-0002-7349-959X
Wang, Fan https://orcid.org/0000-0001-5547-5749
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Text and Data Mining valid from 2026-04-03

Version of Record valid from 2026-04-03
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Article History

Received: 20 November 2025

Accepted: 12 March 2026

First Online: 3 April 2026

Declarations

:

: No author has an actual or perceived conflict of interest with the contents of this article.