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A Mechanistic Framework Integrating Renal QSP-PK-PD and Machine Learning for Baseline-Informed Stratification of Diuretic Resistance

Crossref DOI link: https://doi.org/10.1208/s12248-026-01255-6

Published Online: 2026-05-23

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhou, Jialiang https://orcid.org/0009-0001-6730-8419
Lou, Vingyou https://orcid.org/0009-0005-3429-3846
Zhao, Yixin https://orcid.org/0009-0004-1771-0989
Tang, Linxiu https://orcid.org/0009-0003-1164-4717
Hu, Zihan https://orcid.org/0009-0009-6434-5626
Sun, Jiaqi https://orcid.org/0009-0009-6702-000X
Chen, Jun https://orcid.org/0000-0001-6799-1433
Cheng, Peng https://orcid.org/0009-0005-8648-2630
Cheng, Yu https://orcid.org/0000-0001-8406-6098
He, Hua https://orcid.org/0000-0001-5378-3051
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Text and Data Mining valid from 2026-05-23

Version of Record valid from 2026-05-23
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Article History

Received: 21 January 2026

Accepted: 4 May 2026

First Online: 23 May 2026

Declarations

:

: The authors declared no competing interests for this work.