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Article History

Received: 14 August 2018

First Online: 11 December 2018

Compliance with Ethical Standards

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: Elvire Pons-Tostivint, Youlia Kirova, Amélie Lusque, Mario Campone, Julien Geffrelot, Chafika Mazouni, Audrey Mailliez, David Pasquier, Nicolas Madranges, Nelly Firmin, Agathe Crouzet, Anthony Gonçalves, Clémentine Jankowski, Thibault De La Motte Rouge, Nicolas Pouget, Brigitte de La Lande, Delphine Mouttet-Boizat, Jean-Marc Ferrero, Lionel Uwer, Jean-Christophe Eymard, Marie-Ange Mouret-Reynier, Thierry Petit, Mathieu Robain, Thomas Filleron, Christian Cailliot, and Florence Dalenc declare that they have no conflicts of interest to disclose.

: The present analysis was approved by an independent ethics committee (Comité De Protection Des Personnes Sud-Est II-2015-79). No formal dedicated informed consent was required but all patients had approved the re-use of their electronically recorded data. In compliance with French regulations, the ESME MBC database was authorized by the French data protection authority (authorization no. 1704113).

: Source data (ESME MBC data platform, NCT03275311) are held by UNICANCER on behalf of the 18 FCCCs and are not publicly archived. UNICANCER has established a transfer agreement and use licence with the Biostatistic Center, Institut Claudius Regaud, Toulouse, for this study. The study-specific datasets are archived at the Institut Claudius Regaud, Toulouse.

: This work was supported by R&D UNICANCER. The ESME MBC database is supported by an industrial consortium (Roche, Pierre Fabre, Pfizer, AstraZeneca, MSD, Eisai, and Daiichi Sankyo). Data collection, analyses, and publications are totally managed by R&D UNICANCER independently of the industrial consortium.