Paniccia, Alessandro
Chopra, Asmita
He, Hong-Zhang
Zheng, Si-Yang
Article History
Received: 30 October 2025
Accepted: 4 November 2025
First Online: 19 November 2025
Disclosure
: Si-Yang Zheng is the founder of Captis Diagnostics Inc., which is a participant of this study. The patent for the extracellular vesicle isolation was filed by The Pennsylvania State University, and the patent is pending. Anwaar Saeed reports a consulting or advisory board role with AstraZeneca, Bristol-Myers Squibb, Merck, Exelixis, Pfizer, Xilio Therapeutics, Taiho, Amgen, Autem Therapeutics, KAHR Medical, Arcus Therapeutics, Regeneron, Replimune, and Daiichi Sankyo; institutional research funding from AstraZeneca, Bristol-Myers Squibb, Merck, Clovis, Exelixis, Actuate Therapeutics, Incyte Corporation, Daiichi Sankyo, Five Prime Therapeutics, Amgen, Innovent Biologics, Dragonfly Therapeutics, Oxford Biotherapeutics, Replimune, Phanes Therapeutics, Arcus Therapeutics, Regeneron, and KAHR medical. No potential conflicts of interest were disclosed by the other authors. This work was partially supported by NIH/NCI R01CA230339 awarded to S.-Y.Z, NIH/NCI R43CA228847-01A1 awarded to H.-Z.H, and the Western Pennsylvania Chapter of the National Pancreas Foundation research grant awarded to I.N. and A.P.