Şehitoğlu, Müşerref Hilal http://orcid.org/0000-0003-4436-9160
Öztopuz, Özlem
Karaboğa, İhsan
Ovalı, Mehmet Akif
Uzun, Metehan
Article History
Received: 31 August 2020
Revised: 7 February 2021
Accepted: 18 January 2022
First Online: 11 February 2022
COMPLIANCE WITH ETHICAL STANDARDS
: <i>Conflict of interest</i>. The authors declare that they have no conflicts of interest.
: <i>Statement on the welfare of animals</i>. Our study was approved by Canakkale Onsekiz Mart University Animal Experiments Local Ethics Committee with decision 2018/05-02.
: Humic acid has a healing effect on stomach damage at the histopathological level, Humic acid suppresses iNOS and apoptosis and increases PCNA activity,Humic acid reduces TNF-a and IL-6 levels that are proinflammatory cytokines in the gastric mucosa, while it increases IL-10 levels which is a member of anti-inflammatory cytokines, Humic acid increases ADAM10 and ADAMTS12 levels, these healing effects of humic acid are as strong as famotidine.ADAMTS12 was also present in gastric mucosa for the first time, so ADAMTS12 levels were determined in healthy, gastric ulcer models and humic acid treated groups.